Poalyethylene glycol 800: Yintoni kwaye isetyenziswa phi?

I-Poalyethylene Glytcol 800, okanye i-PEG800 yefutshane, yipolisi ye-polymer eyenziwe yipolisi ye-polymene oxide oxide kunye namanzi. I-PEG800 inyibilikiswa kakhulu kwiingcamango ezifana namanzi, ethanol kunye ne-acetone, kwaye zinokunyibilika ngokukhawuleza kwezi zinyibilikisi ukwenza inkqubo yesicombululo. Olu phawu luyenza ibe yinto efanelekileyo okanye i-smolvent ye-smolven kwimimandla emininzi.

Kwiqondo lokushisa eliqhelekileyo, iipropathi zekhemikhali ze-PEG800 zizinzile kwaye azithathi cala kwi-hydrolysis. Oku kuthetha ukuba ngexesha lokugcina, inokugcina isakhiwo sayo sekhemikhali kunye nentsebenzo engaguquki ixesha elide, ukunciphisa umngcipheko wokuwohloka kwemveliso okubangelwa ziinguqu zemichiza.

I-PEG800 inomsindo ophantsi kakhulu kulusu lomntu kunye ne-mucous membrane. Ikhuselekile kakhulu xa ithathwa ngomlomo okanye isetyenziswe ngokugqibeleleyo kwaye ihlangabezana nokutya okungqongqo kunye nemigangatho yamachiza amayeza. Xa kuthelekiswa ne-peg-molecular-molecular-moleg (efana ne-PEG200 kunye ne-300), i-PEG800 inesimo esiphezulu kunye nefuthe elingcono kunye neziphumo zokonwaba kunye neemveliso zonyango.

Ngexesha lokuqhutywa kwerabha, ukongezwa kwe-PET800 kunganciphisa kakhulu ukuxabana kwangaphakathi phakathi kweemolekyuli zerabha. Ngexesha lenqanaba lokuxuba irabha, inceda iiarhente ezahlukeneyo (ezinje ngeearhente zokungaqhelekanga, iifayile, iifilimu, njl njl) ukuba zisasazeke kakhulu kwi-matrix yerabha, ukuphucula ukusebenza kakuhle kunye nomgangatho. I-PEG800 ikwasetyenziswa kwakhona ukwenzela ukuthambisa iimbaleki.

I-DoTACESM inenzuzo ebalulekileyo ekuboneleleni nge-PET800. Sinenkqubo engqongqo yokulawula umgangatho, eqinisekisa umgangatho ozinzileyo weemveliso ze-PEG800 eziveliswa yi dotrouchem. Zonke izikhombisi ziyadibana okanye zidlula kwimigangatho yecandelo, ziqinisekisa ukuba nganye nganye i-PEG800 ifunyenwe ngabathengi inomgangatho othembekileyo. Wamkelekile ukutyelela iIphepha lemveliso ye-PEG800yeNkampani yeDotachem yokufunda ulwazi lwemveliso ngakumbi kunye neenkcukacha ezi-oda.