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Ngalo lonke ixesha ibhetshi ibanjwa ngenxa yokuba i-solvent ayihambelani nengcaciso, umntu kufuneka achaze ukuba kutheni. Olo hlobo lokuphazamiseka ludibanisa - ngexesha lokuvavanya, ukulibaziseka ukuthunyelwa kwaye ngamanye amaxesha kuhlengahlengiso lwenkqubo olungazange lube yinxalenye yesicwangciso sokuqala. EDotachem, le yimeko esiva ngayo kubathengi rhoqo kunokuba unokulindela.
I-I-Dimethylformamide(DMF)kudla ngokuvela kwezi ncoko. Eyaziwa nangokuthi i-N, N-Dimethylformamide kunye ne-CAS No. Inyibilikisa imathiriyeli ezisokoliswa zezinye izinyibilikisi, ihlala izinzile phantsi kweemeko ezininzi zokusabela, kwaye ixutywa kakuhle namanzi kunye nezinyibilikisi ezahlukeneyo zendalo. Le ndibaniselwano yenza kube nzima ukubuyisela kwiindlela ezithile zokudityaniswa.
Kwi-pharmaceutical intermediate kunye ne-fine chemical synthesis, i-DMF ingasetyenziselwa kwiinkqubo zokuphendula apho ukhetho lwe-solvent lunokuchaphazela ukusebenza kakuhle kokuphendula, ukulawula ukungcola kunye nokuzinza kwenkqubo. I-peptide coupling reactions, i-amide bond formation kunye ne-nucleophilic substitution reactions yimizekelo eqhelekileyo apho i-polar aprotic solvents efana ne-DMF iqwalaselwa. Iqondo lokubilisa elikwiqondo eliphezulu likwavumela ukuba ezinye izenzo ziqhube kumaqondo obushushu anyukileyo ngaphandle kwelahleko ekhawulezayo yokunyibilikisa.
Kwiindlela ezininzi ze-synthesis, ukusebenza kwe-solvent akukona nje ukuchithwa kwezinto zokuqala. Isinyibilikisi esifanelekileyo sinokunceda ukugcina abaphakathi kwisisombululo kuzo zonke izigaba zokusabela, ukunciphisa ukuphazamiseka kwenkqubo okungeyomfuneko kunye nokuxhasa ulawulo lwemveliso oluqikelelwayo. Yiyo loo nto abathengi abaninzi bephatha ukungaguquguquki kweDMF njengenxalenye yomngcipheko wemveliso iyonke, hayi nje iinkcukacha zokuthenga.
Ukungaguquguquki kwe-solvent kudla ngokubaluleke ngakumbi kunokuba kubonakala kuqala. Ukwahluka kwe-Batch-to-batch kumswakama, umbala okanye umkhondo wokungcola kunokudala umsebenzi wovavanyo olongezelelweyo, ukugcinwa kwemveliso enokubakho okanye uhlengahlengiso lwenkqubo ngaphambi kokuba kuqhutyekwe phambili. Ngesi sizathu, abathengi badla ngokugxila ekuzinzeni kwenkcazo kunye nokuthembeka komthengisi, hayi ixabiso kuphela.
Kunxibelelwano olusebenzayo, abathengi abafuna i-DMF kwimichiza ephakathi okanye kwizicelo zeekhemikhali ezilungileyo bahlala bebuza malunga nobunyulu, ukufuma, ubumuncu okanye ialkalinity, inkangeleko, amaxwebhu akhoyo kunye nexesha lokuhamba ngenqanawa. Uninzi lwale mibuzo yehla kwinkxalabo enye: ngaba le nto iya kudala iingxaki kwinkqubo yam?
Njengoko abathengi abaninzi kunye nababoneleli bedibana kwimiboniso yoshishino loxubo-mayeza olufana ne-CPHI, iincoko malunga nokufunyanwa kwe-solvent ziye zasebenza ngakumbi. Abathengi abathelekisi kuphela amagama emveliso okanye iikowuti. Kwakhona bafuna ababoneleli abanokubonelela ngamaxwebhu acacileyo, unxibelelwano oluzinzile olusemgangathweni kunye nenkxaso ngexesha elifanelekileyo xa iishedyuli zokuvelisa zitshintsha.
Njengomthengisi weekhemikhali ezisekelwe eChina, i-Dotachem inikezela nge-Dimethylformamide (DMF) yokuvelisa i-industrial, i-pharmaceutical intermediate synthesis kunye nezicelo ezintle zeekhemikhali. Sixhasa abathengi ngokuqinisekiswa okucacileyo, ukuhlolwa komgangatho, i-COA, i-TDS, i-SDS kunye namaxwebhu athumela ngaphandle ngokweemfuno ze-odolo. Kubathengi abafuna ukubonelela ngokuphindaphindiweyo, iqela lethu linokunceda ngonxibelelwano lokupakisha, ukucwangciswa kokuthunyelwa kunye nenkxaso yexesha elide lokukhangela.
Ngaphaya kwe-DMF, iDotachem ikwaxhasa abathengi ngezinto ezinxulumene nemichiza ekrwada kunye nabaphakathi, njenge.I-I-Monoethanolamine(MEA),Diethanolamine(I-DEA),Ethylenediamine(EDA),Glacial Acrylic Acid(GAA), iMethyl Methacrylate, iMethacrylic Acid,Nonylphenolkunye ne-PTBP. Ezi mveliso zinokuxhasa iimfuno ezibanzi zokukhangela kwimiba yezamayeza, ukuhlanganiswa kweekhemikhali, ukwambathisa, iintlaka, iipolymers kunye neenkqubo zokuqulunqwa kwemizi-mveliso.
Ukuba ujonge i-DMF okanye izinto ezinxulumene nemichiza ekrwada kwimichiza ephakathi okanye kwizicelo zeekhemikhali ezilungileyo,uqhagamshelwanoI-Dotachem yenkcazo yemveliso, amaxwebhu kunye nenkxaso yokubonelela evela eChina.
